Guideline on the peri‐operative management of patients with sickle cell disease

Sickle cell disease is a multisystem characterised by chronic haemolytic anaemia, painful vaso-occlusive crises and acute end-organ damage. It one of the most common serious inherited single gene conditions worldwide has major impact on health affected individuals. Peri-operative complications are higher in patients with sickle compared general population may be or non-sickle-related. Complications reduced meticulous peri-operative care transfusion, but unnecessary transfusion should avoided, particularly to reduce risk allo-immunisation. Planned surgery anaesthesia for ideally undertaken centres experience caring these patients. In an emergency, advice sought from specialists through haemoglobinopathy network arrangements. Emerging data suggest that at increased COVID-19 infection have relatively mild clinical course. Outcomes determined pre-existing comorbidities, as population.